A Cell Map Across Time and Space: The Moscot Framework Fuels a New Revolution in Single-Cell Genomics

Recently, an interdisciplinary research team from the Technical University of Munich, the Helmholtz Zentrum Munich, and ETH Zurich published an important study introducing an innovative framework called Moscot (Multi-Omics Single-Cell Optimal Transport), which successfully reconstructed the developmental trajectories of 1.7 million mouse embryonic cells at 20 time points. This study, published in the journal Nature, marks a significant breakthrough in the field of single-cell genomics. The design inspiration for the Moscot framework comes from the optimal transport theory of the 18th century.